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Experiments

Compound Investigated event Experiment type Concentration Cell line Organism Animal model Stat protein Details
Momelotinib (CYT387) Influence on STAT3 activity in presence of IL6 Flow cytometry 1.50 µM CLBL-1 Canis familriaris p-STAT3
Momelotinib (CYT387) Influence on STAT3 activity in presence of IL6 MFI 1.50 µM CLBL-1 Canis familriaris p-STAT3
Momelotinib (CYT387) Influence on cell apoptosis Flow cytometry 1.00 µM CLBL-1 Canis familriaris
Momelotinib (CYT387) Influence on cell apoptosis Flow cytometry 5.00 µM CLBL-1 Canis familriaris
Momelotinib (CYT387) Influence on cell apoptosis Flow cytometry 1.00 µM MDCK Canis familriaris
Momelotinib (CYT387) Influence on cell apoptosis Flow cytometry 5.00 µM MDCK Canis familriaris
Momelotinib (CYT387) Influence on cell cycle Ki67/DAPI cell proliferation assay 1.00 µM CLBL-1 Canis familriaris
Momelotinib (CYT387) Influence on protein activity in response to TSLP stimulation Western Blot 100.00 nM DC Mus musculus
Momelotinib (CYT387) Influence on protein activity in response to TSLP stimulation Western Blot 100.00 nM DC Mus musculus
Momelotinib (CYT387) Influence on protein activity in response to TSLP stimulation Western Blot 100.00 nM DC Mus musculus
Momelotinib (CYT387) Influence on protein activity in response to TSLP stimulation Western Blot 100.00 nM DC Mus musculus
Momelotinib (CYT387) Influence on protein activity in response to TSLP stimulation Western Blot 100.00 nM DC Mus musculus p-STAT1
Momelotinib (CYT387) Influence on protein activity in response to TSLP stimulation Western Blot 100.00 nM DC Mus musculus STAT1
Momelotinib (CYT387) Influence on protein activity in response to TSLP stimulation Western Blot 100.00 nM DC Mus musculus p-STAT3
Momelotinib (CYT387) Influence on protein activity in response to TSLP stimulation Western Blot 100.00 nM DC Mus musculus STAT3
Momelotinib (CYT387) Influence on protein activity in response to TSLP stimulation Western Blot 100.00 nM DC Mus musculus p-STAT5
Momelotinib (CYT387) Influence on protein activity in response to TSLP stimulation Western Blot 100.00 nM DC Mus musculus STAT5
Momelotinib (CYT387) Influence on surface protein Flow cytometry 100.00 nM DC Mus musculus
Momelotinib (CYT387) Influence on surface protein Flow cytometry 100.00 nM DC Mus musculus
Momelotinib (CYT387) Influence on surface protein Flow cytometry 100.00 nM DC Mus musculus
Momelotinib (CYT387) Influence on surface protein Flow cytometry 100.00 nM DC Mus musculus
Momelotinib (CYT387) Influence on surface protein Western Blot 100.00 nM DC Mus musculus
Momelotinib (CYT387) Influence on surface protein RT-PCR 100.00 nM DC Mus musculus
Momelotinib (CYT387) Influence on inflammatory Th2 cell response Flow cytometry 100.00 nM DC Mus musculus
Momelotinib (CYT387) Influence on cytokine levels ELISA 100.00 nM DC Mus musculus
Momelotinib (CYT387) Influence on cytokine levels ELISA 100.00 nM DC Mus musculus
Momelotinib (CYT387) Influence on cytokine levels ELISA 100.00 nM DC Mus musculus
Momelotinib (CYT387) Influence on Th2 response Histopathological staining 30.00 mg/kg nasal mucosa Mus musculus AR
Momelotinib (CYT387) Influence on Th2 response Western Blot 30.00 mg/kg nasal mucosa Mus musculus AR
Momelotinib (CYT387) Influence on Th2 response Western Blot 30.00 mg/kg nasal mucosa Mus musculus AR
Momelotinib (CYT387) Influence on cytokine levels ELISA 30.00 mg/kg nasal mucosa Mus musculus AR
Momelotinib (CYT387) Influence on cytokine levels ELISA 30.00 mg/kg nasal mucosa Mus musculus AR
Momelotinib (CYT387) Influence on cytokine levels ELISA 30.00 mg/kg nasal mucosa Mus musculus AR
Momelotinib (CYT387) Influence on cytokine levels ELISPOT 30.00 mg/kg nasal mucosa Mus musculus AR
Momelotinib (CYT387) Influence on cytokine levels ELISPOT 30.00 mg/kg nasal mucosa Mus musculus AR